i-Diagnostics and TIRF Analytix – technologies empowering Apollo Program for Biodefense

• Single molecule detection

• Single molecule Forster Resonance Energy Transfer (FRET)

• Super resolution microscopies

• Cell membrane studies

• Molecular diagnostics

• Analysis of biomolecular interactions

• Monitoring real-time kinetics of biomolecular interactions

• Real-time TIRF microarrays

• Combined DNA, RNA, protein, and metabolite arrays

• Studies of protein-protein and protein-DNA interactions

• Studies of surface supported membranes

• Dynamics of lipid rafts studies

• Nanoengineering

• Bioassay development

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    Selected articles published by TIRF Labs' customers are cited in the following Application notes: 

• Lightguide-based Total Internal Reflection Fluorescence and Shallow Angle Fluorescence Microscopy (SAFM) – Novel Methods for Cell Biology Studies

• lg-TIRFM for Neuroscience Studies. Axon Growth and Pathfinding. Studies of Intracellular Pathways that Govern Axon Behavior

• Prism-based TIRFM and lightguide-based TIRFM for Single Molecule Detection Studies

• TIRF-EC – the Utility of ElectroChemical Polarization and Electric Field Control for TIRF Detection

• Molecular mechanisms of baculovirus entry into mammalian cells studied by lgTIRFM, and SAFM combined with other methods

•   TIRF Spectroscopy Application Note 1 Label-Free Continuous Total-Internal-Fluorescence-Based Immunosensor

•   TIRF Spectroscopy Application Note 2 Displacement of Adsorbed Insulin by Tween 80 Monitored Using Total Internal Reflection Fluorescence and Ellipsometry

•   TIRF Spectroscopy Application Note 3 Enzymatic lipid removal from surfaces—lipid desorption by a pH-induced “electrostatic explosion”

•   TIRF Spectroscopy Application Note 4 Regenerable Biosensor Platform: A Total Internal Reflection Fluorescence Cell with Electrochemical Control

•   TIRF Spectroscopy Application Note 5 Adsorption of Poly(ethylene glycol)-Modified Lysozyme to Silica

•   TIRF Spectroscopy Application Note 6 Adsorption of plasma proteins on polyethylene oxide-modified lipid bilayers studied by total internal reflection fluorescence